Table 1. Locus architectures modeled at simulated loci.

Simulated architecture	Direction of effects	Causal variant frequencies	Selection on causal alleles
AR1	All deleterious	Across full SFS	Strong
AR2	All deleterious	Across full SFS	Moderate
AR3	All deleterious	Across full SFS	Weak
AR4	All deleterious	MAF <1%	Strong
AR5	All deleterious	MAF <1%	Moderate
AR6	50% deleterious, 50% protective	Across full SFS	Moderate