Table 1.
Summary of intra-bone bone marrow transplantation
| Animal | Group 1
|
Group 2
|
||||
|---|---|---|---|---|---|---|
| B318 | B324 | B331 | B296 | B336 | B344 | |
| BM cells for IBBM Tx1 (×109 cells/kg) | 4.0 | 5.9 | 3.3 | 1.8 | 3.5 | 3.6 |
| Sites of IBBM Tx | Both tibias | Both tibias | Both tibias | Both tibias | Both tibias | Both tibias, right iliac |
| Percentage of peripheral macrochimerism on POD 2 after IBBM Tx | 5.0 | 4.1 | 1.6 | 0.1 | 29.1 | 13.2 |
| Duration of detectable peripheral macrochimerism (days) | 13 | 6 (Reappeared at day 14) | 10 | 3 (Reappeared at day 10) | 10 | 13 (Reappeared at day 21) |
| BM engraftment (day of biopsy) | – | Positive (19) | Positive (14) | Positive (28) | – | Positive (15) |
| Day of KTx2 | 7 and 13 | 0 | 0 | 73 | 70 and 204 | 62 |
| Excision of kidney graft (days) and serum creatinine (Cre) | 133 and 7 (3.3/1.5) | 19 (1.0) | 14 (1.7) | 173 (3.8) | 133 and 60 (2.3/6.7) | 47 (5.4) |
| Baboon’s survival after IBBM Tx (days) | 27 | 19 | 14 | 90 | 264 | 109 |
| Cause of death | Cardiac death | Pneumonia | Gastrointestinal bleeding | Sacrificed | Sacrificed | Sacrificed |
1
Intra-bone bone marrow transplantation.
2
Days after IBBM Tx.
3
pCMV positive kidneys.