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Pathophysiology of Trauma Induced Coagulopathy
| Protein C Activation | Blocks thrombin formation, enhances fibrinolysis, Antiinflammatory |
| Glycocalyx Disruption | Autoheparinization, enhanced fibrinolysis |
| Platelet Exhaustion | Decreased thrombin generation, decreased clot strength, reduced cellular signaling |
| Fibrinogen Depletion | Decreased clot strength, decreased speed of clot formation |
