Table 3.

Endothelial Injury Studies

Johansson et al. [23]	Ann Surg 2011; 254:194-200	Prospective Clinical, 75 trauma patients	Single Center	High circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality
Ostrowski [21]	J Trauma Acute Care Surg. 2012 Jul; 73(1): 60-6.	Prospective Observational, 77 patients	Single Center	Acute endogenous coagulopathy with autoheparinization by TEG appeared mechanistically linked to endothelial glycocalyx degradation.
Ostrowski [24]	Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:27	Prospective Observational, 80 trauma patients	Single Center	Sympathoadrenal activation, shock and inflammation may be critical drivers of endothelial activation and damage early after trauma