Table 5.

Platelet Dysfunction Studies

Wohlauer et al. [31]	J Am Coll Surg. 2012 May; 214(5): 739-746.	Prospective, 51 patient samples	Single Center	Impairment of platelet function in response to AA was 44.9% (IQR 26.6-59.3%), compared to 0.5% (IQR 0-3.02%) in volunteers
Donahue et al.[32]	Journal of Neurotrauma. 2014 Feb; 31:404-410	Rodent Model	Single Center	Large decrease in platelet stimulation toward ADP, AA, and collagen after blunt force head trauma
Kutcher et al. [30]	J Trauma Acute Care Surg. 2012 July; 73(1): 13-19.	Prospective, 101 patients	Single Center	Clinically significant platelet dysfunction after trauma in the presence of an otherwise reassuring platelet count and standard clotting studies, with profound implications for mortality.
Kornblith et al. [25]	J Trauma Acute Care Surg. 2014 Feb; 76(2): 255-6; discussion 262-3.	Prospective, 251 patients	Single Center	Coagulopathic patients (international normalized ratio ≥ 1.3) had significantly lower admission %MA (FF) than noncoagulopathic patients (24.7% vs. 31.2%, p < 0.05). Despite this importance of fibrinogen, platelets had a greater contribution to clot strength at all time points after injury.