Table 1. Definitions of outcome events.

Event	Definition
Ischemic stroke	Relevant clinical features that caused an increase in impairment of at least one grade on the modified Rankin scale21 associated with a relevant infarction on a repeat brain scan.
Myocardial infarction	At least two of the following criteria:
	1: Chest pain >20 min, not disappearing after administration of nitrates
	2: ST elevation >1 mm in two following leads or a left bundle branch block
	3:CK elevation of at least two times its normal value and an MB fraction >5% of total CK
Vascular death: not due to hemorrhage	Sudden death: unexpected coronary death occurring within 1 h after onset of symptoms or within 24 h given convincing circumstantial evidence.
	Terminal heart failure
	Fatal myocardial infarction or ischemic stroke

Primary outcome was defined as all fatal and non-fatal ischemic events. Secondary outcome was ischemic stroke separately.