Table 3. Cox proportional hazard models and AUC-ROC.

	M1		M2
Indicator	HR	95% CI	HR	95% CI
Demographic characteristics
Male	1.47	1.06–2.04	1.35	0.86–2.11
Age	1.05	1.03–1.06	1.02	1.00–1.04
History
Myocardial infarction	1.78	1.25–2.55	1.72	1.03–2.87
Hypertension	1.08	0.82–1.43	1.56	1.05–2.33
Intermittent Claudication	1.76	1.14–2.72	1.55	0.80–2.97
Diabetes Mellitus	1.37	0.96–1.97	1.34	0.81–2.24
Vascular surgery	1.79	1.30–2.46	1.50	0.93–2.40
Genetic risk score	1.13	0.92–1.38	1.17	0.91–1.50
AUC-ROC
Only classical risk factors	0.65	0.61–0.69	0.60	0.54–0.65
Plus genetic risk core	0.66	0.61–0.70	0.60	0.54–0.66

Table displays univariable analyses of risk factors for vascular disease for different endpoints. The bold numbers are accounted in the multivariable model with and without genetic risk scores. AUC-ROC = Area Under Curve of the Receiver Operating Characteristics Curve. M1 = primary outcome. M2 = secondary outcome, ischemic stroke