Table 2. Meta-analysis of the association between SLE and thyroid autoimmunity.
| Type of antibody | Eligible studies | OR (95% CI) | P value | Heterogeneity test | Effect model |
|---|---|---|---|---|---|
| TgAb | |||||
| Asian | 3 | 5.43 (0.76–39.10) | 0.093 | P-H = 0.010, I 2 = 78.2% | Random |
| African | 4 | 2.44 (0.56–10.70) | 0.236 | P-H = 0.048, I 2 = 62.0% | Random |
| American | 3 | 4.03 (2.08–7.80) | 0.000 | P-H = 0.560, I 2 = 0% | Fixed |
| European | 5 | 1.81 (1.23–2.65) | 0.002 | P-H = 0.673, I 2 = 0% | Fixed |
| Total | 15 | 2.99 (1.83–4.89) | 0.000 | P-H = 0.013, I 2 = 50.4% | Random |
| TPOAb | |||||
| Asian | 1 | 0.66 (0.16–2.76) | 0.566 | —— | Fixed |
| African | 4 | 4.55 (1.33–15.49) | 0.016 | P-H = 0.027, I 2 = 67.3% | Random |
| American | 2 | 1.10 (0.55–2.24) | 0.783 | P-H = 0.296, I 2 = 8.5% | Fixed |
| European | 4 | 2.32 (1.62–3.32) | 0.000 | P-H = 0.185, I 2 = 37.9% | Fixed |
| Total | 11 | 2.20 (1.27–3.82) | 0.005 | P-H = 0.003, I 2 = 62.5% | Random |
TgAb: thyroglobulin antibody. TPOAb: thyroid peroxidase antibody.