Table 2. Diseases and biological functions for ZNF804A down-regulated genes.
| Diseases/Functions | p-value | Molecules |
|---|---|---|
| neuromuscular disease | 1.56E-08 | ADRA2A,AEBP1,AK5,ALDH6A1,APOE,ATP2B2,BRINP1,CCL2,CDS1,CHRM3,CNR1,CPNE5,CRYAB,CRYM,DGKB,ESRRG,FAS,FLRT2,GABRA2,GRIK2,HAP1,HCG22,IFNAR1,ITPKB,KCNA5,KCNAB1,KCND2,KCNIP1,MX1,NR4A2,PCDH7,PDE4B,PPARA,PPP3CA,PRNP,PSMB8,RXRG,SCARB2,SCN2A,SCN4B,SEZ6,SH3GL2,SLC1A1,SLC24A3,SPOCK3,ST8SIA4,TM2D1,TOMM20,TPD52 |
| dyskinesia | 1.31E-07 | ADRA2A,AEBP1,ALDH6A1,APOE,ATP2B2,CDS1,CHRM3,CNR1,CPNE5,CRYAB,CRYM,DGKB,ESRRG,FLRT2,GABRA2,GRIK2,HAP1,ITPKB,KCNA5,KCNAB1,KCNIP1,PCDH7,PPARA,PPP3CA,PSMB8,RGS2,RXRG,SCARB2,SCN2A,SCN4B,SEZ6,SLC1A1,SPOCK3,TM2D1,TOMM20,TPD52 |
| Movement Disorders | 2.46E-07 | ADRA2A,AEBP1,ALDH6A1,APOE,ATP2B2,BEAN1,CA5B,CDS1,CHRM3,CNR1,CPNE5,CRYAB,CRYM,DGKB,ESRRG,FAS,FLRT2,GABRA2,GRIK1,GRIK2,HAP1,ITPKB,KCNA5,KCNAB1,KCNC3,KCNIP1,KLHL1,NR4A2,PCDH7,PDE4B,PPARA,PPP3CA,PSMB8,RGS2,RXRG,SCARB2,SCN2A,SCN4B,SEZ6,SH3GL2,SLC1A1,SPOCK3,ST8SIA4,TM2D1,TOMM20,TPD52 |
| Huntington's Disease | 3.01E-07 | AEBP1,ALDH6A1,APOE,ATP2B2,CDS1,CHRM3,CNR1,CPNE5,CRYAB,CRYM,DGKB,ESRRG,FLRT2,GABRA2,GRIK2,HAP1,ITPKB,KCNA5,KCNAB1,KCNIP1,PCDH7,PPARA,PPP3CA,PSMB8,RXRG,SCARB2,SCN2A,SCN4B,SEZ6,SLC1A1,SPOCK3,TM2D1,TOMM20,TPD52 |
| Schizophrenia | 5.13E-07 | ADRA2A,ALDH3B1,ALDH5A1,APOE,ATP2B2,CALY,CCK,CHRM3,CNR1,CRYM,CXCL12,DAB1,EBF1,ELAVL4,GABRA2,GRIA4,GRID1,GRIK1,GRIK2,GRIK4,GRM5,HIST1H2BN,MCHR1,NELL1,PLA2G4C,PPARA,RXRG,SLC12A2,SLC12A5,SLC1A1,SLC6A1,SLIT3,SNRK,TF |
| disorder of basal ganglia | 8.33E-07 | ADRA2A,AEBP1,ALDH6A1,APOE,ATP2B2,CDS1,CHRM3,CNR1,CPNE5,CRYAB,CRYM,DGKB,ESRRG,FLRT2,GABRA2,GRIK2,HAP1,ITPKB,KCNA5,KCNAB1,KCNIP1,NR4A2,PCDH7,PDE4B,PDE8B,PPARA,PPP3CA,PSMB8,RGS2,RXRG,SCARB2,SCN2A,SCN4B,SEZ6,SH3GL2,SLC1A1,SPOCK3,ST8SIA4,TM2D1,TOMM20,TPD52 |
| progressive motor neuropathy | 3.73E-06 | ADRA2A,AK5,ALDH5A1,APOE,BRINP1,CCL2,CDKN1A,CHRM3,CNR1,CRYAB,DAB1,FAS,GABRA2,HCG22,HRK,IFNAR1,KCND2,MX1,NR4A2,PDE4B,PLA2G4C,PRNP,SCN2A,SCN4B,SH3GL2,SLC1A1,SLC24A3,SPARC,ST8SIA4,SUSD1,TIMP1 |
| epilepsy | 1.12E-05 | ALDH5A1,ARRDC3,ASAH1,CA5B,CDKN1A,CRYM,ERRFI1,GABRA2,GRIK1,KAL1,LINC00152,NR4A3,PRICKLE1,PRNP,RGS2,SCARB2,SCN2A,SCN4B,SLC6A1,TRIM9 |
| bipolar disorder | 3.32E-05 | ADRA2A,ALDH5A1,APOE,CA5B,CCL2,CHRM3,GABRA2,GRIA2,GRID1,GRIK1,GRIK2,GRIK4,GRM5,MCHR1,PPP2R2C,PPP3CA,RABGAP1L,SCN2A,SCN4B,SLC1A1,TCF4 |
| inflammatory demyelinating disease | 6.41E-05 | ADRA2A,AK5,BRINP1,CCL2,CHRM3,CNR1,CRYAB,FAS,HCG22,IFNAR1,KCND2,MX1,SLC24A3,TIMP1 |
This included several kainate ionotrophic receptors, AMPA and metabotropic glutamate receptor subtypes, and the GABA-A receptor subtype, GABRA2 [67]. In addition, a decrease in cholecystokinin expression was detected in the KD neurons. CCK codes for a neuropeptide that’s expressed in a subset of GABAergic neurons; it has a role in mediating anxiety traits and panic disorder, and is differentially expressed in the entorhinal cortex in SZ [68–72].