Table 3.
Effect of glycaemic control on plasma levels of mannan-binding lectin-associated serine proteases (MASPs) in adults with type 1 diabetes mellitus (T1DM)
| Baseline | After improvement of glycaemic control | P-value* for intra-individual change | |
|---|---|---|---|
| All patients in this subgroup (n = 26) | |||
| HbA1c (%) | 9·8 (9·2; 11·1) | 9·0 (7·9; 10·5) | 0·001 |
| MASP-1 (μg/ml) | 16·5 (14·8; 20·2) | 15·4 (13·4; 18·7) | 0·078 |
| MASP-2 (ng/ml) | 452·9 (315·7; 575·5) | 362·6 (237·3; 537·0) | 0·170 |
| MASP-3 (μg/ml) | 4·7 (4·1; 5·7) | 4·6 (3·9; 5·5) | 0·069 |
| MAp44 (μg/ml) | 2·0 (1·7; 2·2) | 1·8 (1·6; 2·1) | 0·054 |
| Patients whose glycaemic control improved most (HbA1c down by at least 10%) (n = 12) | |||
| HbA1c (%) | 10·4 (9·3; 14·1) | 8·2 (7·1; 9·7) | 0·002 |
| MASP-1 (μg/ml) | 16·9 (15·2; 21·5) | 14·9 (12·8; 18·5) | 0·012 |
| MASP-2 (ng/ml) | 487·1 (350·0; 649·7) | 441·5 (316·7; 635·9) | 0·136 |
| MASP-3 (μg/ml) | 5·3 (4·1; 6·5) | 4·8 (3·8; 5·4) | 0·011 |
| MAp44 (μg/ml) | 1·9 (1·7; 2·2) | 1·8 (1·7; 2·3) | 0·625 |
Data are shown as median (25th percentile; 75th percentile). n = number.
*
Wilcoxon's signed-rank test. Map44 = mannose-binding lectin-associated protein; HbAlc = glycated haemoglobin type A1c.