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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Exp Cell Res. 2014 Nov 26;333(2):201–207. doi: 10.1016/j.yexcr.2014.11.013

Figure 1. Regulation of HIF-1α by LPA.

Figure 1

A. Under basal conditions, p53 functions as a negative regulator of Hif1α promoter. B. LPA stimulates Mdm2, which ubiquitinates and degrades p53. At the same time, LPA induces expression of KLF5 that transactivates Hif1α promoter and transcribes HIF1α mRNA. C. However, mutant p53 is resistant to LPA-mediated degradation of p53. Although KLF5 is induced by LPA in cells harboring mutant p53, KLF5 is unable to displace mutant p53 [33].