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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Exp Cell Res. 2014 Nov 26;333(2):201–207. doi: 10.1016/j.yexcr.2014.11.013

Figure 2. Regulation of intestinal transport by LPA.

Figure 2

LPA5 stimulates Na+ absorption by activation of NHE3 in the villus [9]. Regulation of NHE3 is mediated by transactivation of EGFR, which activates the RhoA-ROCK-Pyk2 and MEK-ERK pathways converging onto NHE3 [52]. In the crypt compartment, LPA2 decreases cAMP generation by cholera toxin, leading to inhibition of CFTR Cl− channel [50].