Table 2.
DXA measures of bone mineral density.
| Characteristic | FA HCT [A] | Cancer HCT [B] | Healthy controls [C] | Pairwise P values |
||
|---|---|---|---|---|---|---|
| A vs C | A vs B | B vs C | ||||
| n | 20 | 13 | 90 | - | - | - |
|
Total body BMD Z-score | ||||||
| TBMDage Z-score (mean ± SD) | −1.3 (1.0) | −0.2 (0.7) | 0.7 (1.0) | <0.0001 | <0.0001 | 0.006 |
| TBMDHAZ Z-score (mean ± SD) | −0.8 (0.9) | −0.5 (0.8) | 0.01 (0.9) | 0.0004 | 0.16 | 0.11 |
| TBMDage Z-score ≤ −1, n (%)a | 13 (65) | 2 (15) | 3 (3) | <0.0001 | 0.0096 | 0.09 |
| TBMDHAZ Z-score ≤ −1, n (%)b | 8 (42) | 4 (31) | 10 (11) | 0.0032 | 0.24 | 0.02 |
|
Lumbar spine BMD Z-score | ||||||
| LBMDage Z-score (mean ± SD) | −0.9 (1.1) | −0.2 (0.9) | 0.2 (1.0) | 0.0003 | 0.04 | 0.62 |
| LBMDHAZ Z-score (mean ± SD) | 0.08 (0.9) | 0.04 (0.9) | 0.02 (1.0) | 0.77 | 0.91 | 0.94 |
| LBMDage Z-score ≤ −1, n (%) | 10 (50) | 3 (23) | 9 (10) | <0.0001 | 0.62 | 0.0032 |
| LBMDHAZ Z-score ≤ −1, n (%) | 1 (5) | 2 (15) | 11 (12) | 0.45 | 0.23 | 0.51 |
BMDage Z-score is based on chronological age and sex; BMDHAZ Z-score indicates adjustment for height-for-age Z-score (HAZ) using the approach of Zemel et al. JCEM 2010.
a
TBMD data were missing for 2 controls.
b
Height or TBMD data were missing for 2 controls and 1 FA patient.
cLBMD data were missing for 1 control.
dHeight or LBMD data were missing for 1 control and 1 FA patient. To account for multiple comparisons, P value <0.0167 is considered statistically significant using a Bonferroni adjustment (marked in bold).