Table 1.
Genes differentially expressed in Rs1 expressing OBs compared to controls
| Gene symbol | Gene name | Mean ratio (Rs1/control) | p-value |
|---|---|---|---|
| Growth factor | |||
| Figf | c-fos induced growth factor | 2.08 | 1.6×10−4 |
| Fgf9 | fibroblast growth factor 9 | 0.63 | 4.0×10−5 |
| Transcription factor and regulator | |||
| Dennd4a | DENN/MADD domain containing 4A | 1.99 | 1.1×10−3 |
| Ldb2 | LIM domain binding 2 | 1.79 | 6.6×10−3 |
| Hmgb3 | high mobility group box 3 | 1.72 | 8.3×10−3 |
| Mlx | MAX-like protein X | 1.61 | 9.0 ×10−5 |
| Asxl2 | additional sex combs like 2 (Drosophila) | 0.65 | 4.1×10−3 |
| Supt7l | suppressor of Ty 7 (S. cerevisiae)-like | 0.63 | 1.6×10−3 |
| Tceal5 | transcription elongation factor A (SII)-like 5 | 0.62 | 9.2×10−3 |
| Ddx1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 | 0.58 | 4.0×10−5 |
| Nfxl1 | nuclear transcription factor, X-box binding-like 1 | 0.56 | 9.6×10−4 |
| Zbtb20 | zinc finger and BTB domain containing 20 | 0.53 | 4.1×10−3 |
| Samd9l | sterile alpha motif domain containing 9-like | 0.44 | 5.1×10−3 |
| Bex1 | brain expressed gene 1 | 0.37 | 8.5×10−4 |
| Cell cycle regulator | |||
| Fbxo5 | F-box protein 5 | 1.97 | 8.4×10−3 |
| Tubb3 | tubulin, beta 3 | 1.93 | 1.3×10−3 |
| Cdc2a | cell division cycle 2 homolog A (S. pombe) | 1.84 | 1.0×10−3 |
| Lsm10 | U7 snRNP-specific Sm-like protein LSM10 | 1.69 | 5.0×10−3 |
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 1.65 | 6.8×10−3 |
| Casc5 | cancer susceptibility candidate 5 | 1.57 | 7.4×10−3 |
| Prc1 | protein regulator of cytokinesis 1 | 1.56 | 3.2×10−3 |
| Anln | anillin, actin binding protein | 1.55 | 5.1×10−3 |
| Elovl1 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 | 1.54 | 3.5×10−3 |
| Ndc80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | 1.53 | 7.5×10−3 |
| Cdkn2b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 1.53 | 3.5×10−3 |
| Cdca2 | cell division cycle associated 2 | 1.51 | 1.3×10−3 |
| Cspp1 | centrosome and spindle pole associated protein 1 | 0.26 | 3.0×10−3 |
| Regulation of apoptosis | |||
| Bard1 | BRCA1 associated RING domain 1 | 1.78 | 5.3×10−3 |
| Trp53inp1 | transformation related protein 53 inducible nuclear protein 1 | 0.61 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.48 | 6.8×10−3 |
| Trim13 | tripartite motif-containing 13 | 0.44 | 9.9×10−3 |
| Clec2d | C-type lectin domain family 2, member | 0.43 | 7.8×10−3 |
| Casp1 | caspase 1 | 0.26 | 1.6×10−4 |
| Enzyme activity | |||
| Car8 | carbonic anhydrase 8 | 1.85 | 8.2×10−3 |
| Slpi | Secretory leukocyte peptidase inhibitor | 1.81 | 4.4×10−3 |
| Adat2 | adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae) | 1.64 | 1.4×10−3 |
| Xdh | xanthine dehydrogenase | 1.62 | 9.3×10−3 |
| Sae1 | SUMO1 activating enzyme subunit 1 | 1.55 | 1.1×10−3 |
| Got1 | glutamate oxaloacetate transaminase 1, soluble | 1.52 | 5.0×10−5 |
| Ctdspl2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.66 | 3.8×10−3 |
| Dub2a | deubiquitinating enzyme 2a | 0.64 | 4.4×10−3 |
| Car2 | carbonic anhydrase 2 | 0.62 | 8.7×10−3 |
| Gstm1 | glutathione S-transferase, mu 1 | 0.60 | 8.0×10−3 |
| Ppp1r12b | protein phosphatase 1, regulatory (inhibitor) subunit 12B | 0.48 | 5.9×10−3 |
| Lipid and carbohydrate metabolic process | |||
| Lipi | Lipase, member I | 4.63 | 9.0×10−5 |
| Idi1 | isopentenyl-diphosphate delta isomerase | 2.21 | 1.6×10−3 |
| Fabp3 | fatty acid binding protein 3, muscle and heart | 1.69 | 2.2×10−4 |
| Me1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 1.60 | 7.7×10−3 |
| Gpr116 | G protein-coupled receptor 116 | 0.49 | 8.3×10−3 |
| Transporter | |||
| Slc35a1 | solute carrier family 35 (CMP-sialic acid transporter), member 1 | 1.83 | 1.8×10−3 |
| Efha1 | EF hand domain family A1 | 1.67 | 1.5×10−3 |
| Arfgef2 | ADP-ribosylation factor guanine nucleotide | 0.66 | 1.4×10−3 |
| Trappc2l | trafficking protein particle complex 2-like | 0.63 | 2.3×10−3 |
| Mfsd7b | major facilitator superfamily domain containing 7B | 0.53 | 2.2×10−3 |
| Atp6v1b2 | ATPase, H+ transporting, lysosomal V1 subunit B2 | 0.53 | 1.0×10−3 |
| Atp6v0d2 | ATPase, H+ transporting, lysosomal V0 subunit D2 | 0.26 | 6.7×10−3 |
| Kinase activity | |||
| Prkrip1 | Prkr interacting protein 1 (IL11 inducible) | 1.66 | 3.6×10−3 |
| Lmnb1 | lamin B1 | 1.54 | 1.8×10−4 |
| Fgd4 | FYVE, RhoGEF and PH domain containing 4 | 0.62 | 4.2×10−3 |
| Adrbk2 | adrenergic receptor kinase, beta 2 | 0.61 | 3.5×10−3 |
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.61 | 2.4×10−3 |
| Ptpn3 | protein tyrosine phosphatase, non-receptor type 3 | 0.44 | 4.2×10−3 |
| Protein binding | |||
| Mrpl17 | mitochondrial ribosomal protein L17 | 2.27 | 5.5×10−3 |
| Iqcb1 | IQ calmodulin-binding motif containing1 | 0.62 | 2.9×10−3 |
| Ppfia2 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 | 0.59 | 3.2×10−3 |
| Cytoskeleton | |||
| Dync2li1 | dynein cytoplasmic 2 light intermediate chain 1 | 1.71 | 1.0×10−3 |
| Plekhh2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member2 | 0.64 | 3.0×10−3 |
| Syne2 | synaptic nuclear envelope 2 | 0.30 | 5.0×10−5 |
| Solute carrier | |||
| Slc38a4 | solute carrier family 38, member 4 | 1.91 | 3.3×10−3 |
| Slc25a19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 | 0.58 | 5.7×10−3 |
| Slc5a3 | solute carrier family 5 (inositol transporters), member 3 | 0.50 | 2.4×10−4 |
| Immune system | |||
| Cd1d1 | CD1d1 antigen | 1.89 | 4.2×10−3 |
| Srgn | Serglycin | 0.48 | 3.9×10−3 |
| Organogenesis | |||
| Rbp4 | Retinol binding protein 4, plasma | 1.69 | 4.7×10−4 |
| Lmbr1 | limb region 1 | 0.53 | 7.9×10−3 |
| Aard | alanine and arginine rich domain containing protein | 0.51 | 4.0×10−5 |
| Nucleoside/nucleotide metabolic process | |||
| Mtap | methylthioadenosine phosphorylase | 1.53 | 3.0×10−3 |
| Gpatch8 | G patch domain containing 8 | 0.62 | 2.7×10−3 |
| Rbm47 | RNA binding motif protein 47 | 0.60 | 6.9×10−3 |
| Gimap6 | GTPase, IMAP family member 6 | 0.57 | 8.4×10−3 |
| Rab30 | RAB30, member RAS oncogene family | 0.57 | 3.2×10−3 |
| Gtpbp10 | GTP-binding protein 10 (putative) | 0.45 | 3.1×10−3 |
| Membrane protein | |||
| Tmem43 | transmembrane protein 43 | 1.62 | 6.8×10−3 |
| Tm4sf1 | transmembrane 4 superfamily member 1 | 1.61 | 2.0×10−5 |
| Neto2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.66 | 9.5 ×10−4 |
| Tm4sf19 | transmembrane 4 L six family member19 | 0.64 | 6.1×10−3 |
| Tspan13 | tetraspanin 13 | 0.63 | 9.4×10−3 |
| Fam171b | family with sequence similarity 171, member B | 0.59 | 2.8×10−3 |
| Tspan7 | tetraspanin 7 | 0.53 | 7.6×10−3 |
| Coagulation cascades | |||
| Thbd | Thrombomodulin | 0.57 | 1.7×10−4 |
| Erythrocyte homeostasis | |||
| Fech | Ferrochelatase | 0.61 | 6.1×10−3 |
| Ossification | |||
| Ostn | Osteocrin | 0.31 | 3.7×10−3 |
| Signal transduction | |||
| Rras2 | related RAS viral (r-ras) oncogene homolog 2 | 2.05 | 8.1×10−4 |
| Srgap3 | SLIT-ROBO Rho GTPase activating protein 3 | 0.65 | 4.8×10−4 |
| Angiogenesis | |||
| Mfge8 | Milk fat globule-EGF factor 8 protein | 1.50 | 4.2×10−3 |
| Cell adhesion molecule | |||
| Pcdhb17 | protocadherin beta 17 | 1.68 | 3.8×10−3 |
| Ion channel | |||
| Kcnj15 | potassium inwardly-rectifying channel, subfamily J, member 15 | 1.98 | 7.7×10−4 |
| Kcnk1 | potassium channel, subfamily K, member 1 | 1.53 | 2.2×10−4 |
| Wdfy2 | WD repeat and FYVE domain containing2 | 0.65 | 5.2×10−3 |
| Zfp788 | zinc finger protein 788 | 0.63 | 5.2×10−3 |
| Phf20l1 | PHD finger protein 20-like 1 | 0.63 | 1.9×10−3 |
| Zfp763 | zinc finger protein 763 | 0.55 | 1.5×10−3 |
| Matrix protein | |||
| Ecm1 | extracellular matrix protein 1 | 1.61 | 1.9×10−3 |
| Chad | Chondroadherin | 0.65 | 9.0×10−3 |
| Cytokine secretion | |||
| Irf1 | interferon regulatory factor 1 | 0.60 | 3.2×10−3 |
| Lcp2 | lymphocyte cytosolic protein 2 | 0.47 | 8.1×10−3 |
| Other | |||
| Lgals2 | lectin, galactose-binding, soluble 2 | 3.31 | 9.0 ×10−5 |
| Fv1 | Friend virus susceptibility 1 | 2.11 | 1.0 ×10−4 |
| Fam84a | family with sequence similarity 84, member A | 1.80 | 1.2×10−3 |
| Mpv17 | Mpv17 transgene, kidney disease mutant | 1.72 | 7.7×10−3 |
| Thada | thyroid adenoma associated | 1.63 | 2.4×10−4 |
| Myg1 | melanocyte proliferating gene 1 | 1.55 | 3.5×10−3 |
| Prosc | proline synthetase co-transcribed | 0.62 | 8.1×10−3 |
| Hmcn1 | hemicentin 1 | 0.36 | 5.0×10−3 |
*
Values are mean ratio of the Rs1 vs. control among the 6 samples, P<0.01 in microarray data