Table 1.

Articles published on social media mining for ADR detection, their years of publication, data sources, domains of focus, numbers of drugs, size of data, and annotations and public availability of the data.

Study	Year	Source	Sub-domain	# drugs	# instances	Annotations/ Available
Leaman et al. [17]	2010	DailyStrength [13]	-	6	3,600	Yes/No
Nikfarjam and Gonzalez [34]	2011	DailyStrength [13]	-	4	1,200	Yes/No
Chee et al. [40]	2011	Yahoo! groups	-	435	1,200,000	No
Benton et al. [42]	2011	various forums5	Breast cancer	4	1,100,000	No
Hadzi-puric and Grmusa [43]	2012	eight parenting forums	Pediatrics	9	1,290	Yes/No
Yang et al. [44]	2012	MedHelp [14]	5 ADRs	10	6,2446	No
Bian et al. [45]	2012	Twitter	Cancer	5	2,000,000,000	No
Liu and Chen [46]	2013	American Diabetes Association [47]	Diabetes	-	1,348,364	No7
Yang et al. [48]	2013	Yahoo! groups	-	2	6,400	Yes/No
Jiang and Zheng [49]	2013	Twitter	-	5	885	Yes/No
Yates and Goharian [50]	2013	AskAPatient [51], Drugs.com [52], DrugRatingZ [53]	Breast cancer	5	2,5008	Yes/Yes
Yeleswarapu et al.9 [54]	2014	PatientsLikeMe [55], Daily Strength [13], MediGuard [56]	-	1210	13,50011	No
Freifeld et al. [57]	2014	Twitter	-	23	60,000	No
Segura et al. [58]	2014	ForumClinic [59]	-	18712	400	Yes/Yes
Ginn et al. [38]	2014	Twitter	-	74	10,822	Yes/Yes
Liu et al. [60]	2014	MedHelp [14]	Heart disease	-	600	Yes/No
Patki et al. [39]	2014	DailyStrength	-	38	10,617	Yes/No
O'Connor et al. [35]	2014	Twitter	-	54	1,873	Yes/Yes
Yang et al. [61]	2014	MedHelp [14]	-	10, 5 ADRs	-	No/No
Sampathkumar et al. [62]	2014	Medications.com [63], Steady- Health [64]	-	-	2,000	Yes/No
Sarker and Gonzalez 13 [41]	2014	Twitter, Daily Strength [13]	-	74 for Twitter, 56 for Daily Strength	10,822 for Twitter, 10,617 for Daily Strength	Yes/Yes
Nikfarjam et al. [65]	2014	Twitter, Daily Strength [13]	-	81	6,279 for Daily Strength, 1,784 for Twitter	Yes/Yes