Table 5.

Results of a paired t-test comparing fMRI signal change differences (post-treatment pain>pre-treatment pain) between nocebo and neutral control, as well as between placebo and neutral control.

Contrast	Voxels	Brain area	Peak Coordinate (x, y, z)	Z value
Neutral > Negative Exp	75	L hippocampus	14, −10, −22	3.30 svc
	100	R hippocampus	−28, −10, −24	3.36 svc
	38	L amygdala	16, −2, −20	3.47 svc
	100	R amygdala	−26, −10, −22	3.22 svc
	402	L superior temporal sulcus	32,0, −42	3.71
	218	R superior temporal sulcus	−54,14, −26	3.69
Negative Exp > Neutral	no brain region above the threshold
Neutral > Positive Exp	151	R putamen	−28,2, −6	3.86 svc
	37	L caudate	8,10,6	3.35 svc
	8	R ventral striatum	−10,8, −6	2.83 svc
	26	L ventral striatum	10,8, −12	3.16 svc
	217	L ventromedial PFC	8,58, −2	3.34 svc
	4848	L occipital cortex	14, −72,18	4.04
		L precentral gyrus	44, −16,30	4.41
Positive Exp >Control	no brain region above the threshold
Negative Exp > Positive Exp	5	R periaqueductal grey	−2,−28,−6	2.97 svc
	143	R anterior insula	−26,20,−2	3.79 svc
	61	R orbitofrontal cortex	−38,46,−4	3.83 svc
Positive Exp > Negative Exp	99	L ventral striatum	12,8,−10	3.85 svc

PFC=prefrontal cortex, L=left, R=right. For regions of interest (ROI), results were significant at P^FWE<0.05 after small volume correction (svc). Other results were significant at voxelwise p<0.005, uncorrected for 20 contiguous voxels.