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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Trends Biochem Sci. 2015 Apr 13;40(5):257–264. doi: 10.1016/j.tibs.2015.03.005

Figure 1. Integrator subunit domain schematic.

Figure 1

Predicted protein domains of all 14 Integrator subunits are illustrated and the length of the human orthologues is indicated (in amino acids, aa). DUF=domain of unknown function, ARM=armadillo like repeats, VWA=von Willebrand type A like domain, ISDCC=INTS6/SAGE1/DDX26B/CT45 C-terminus, TPR=tetratricopeptide repeats, β-lactamase/β-CASP (see glossary) “*” indicates the presence of an inactive β-lactamase/β-CASP domain, PHD=plant homeodomain finger, COIL=Coiled coil domain. Identified interacting domains with other proteins are underlined.