Predicted protein domains of all 14 Integrator subunits are illustrated and the length of the human orthologues is indicated (in amino acids, aa). DUF=domain of unknown function, ARM=armadillo like repeats, VWA=von Willebrand type A like domain, ISDCC=INTS6/SAGE1/DDX26B/CT45 C-terminus, TPR=tetratricopeptide repeats, β-lactamase/β-CASP (see glossary) “*” indicates the presence of an inactive β-lactamase/β-CASP domain, PHD=plant homeodomain finger, COIL=Coiled coil domain. Identified interacting domains with other proteins are underlined.