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Stability of compounds 9 and 5 incubated in mouse serum and analyzed at different intervals of time. The amount of remaining intact peptide was detected by mass spectrometry using freshly prepared compound 8 an analog of compounds 9 and 5 as internal standard. A) compound 9, B) compound 5. Compound 5 was more stable compared to compound 9 in serum as seen from the graph.
