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Confocal images of PLA on breast tumor sections. A) PLA on control mouse without any treatment. Red color fluorescence indicate HER2:HER3 heterodimerization. PLA on mouse treated with 4 mg/kg of B) compounds 9 and C) 5. Compounds specifically inhibited HER2:HER3 heterodimerization significantly compared to the control without any treatment as indicated by the small number of red dots.
