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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Neuroscience. 2015 Mar 27;295:126–138. doi: 10.1016/j.neuroscience.2015.03.051

Figure 1. TIC injury induced mechanical and cold allodynia.

Figure 1

Mice with TIC injury were tested for mechanical allodynia on the whisker pad and thermal hypersensitivity in the V2 area behind the whisker pad (A). The ipsilateral whisker pad mechanical threshold of the mice with TIC injury was significantly decrease compared to that of the contralateral side and the sham and naïve mice within the first week post injury. The decreased threshold persisted until euthanasia at 21weeks post injury (B). The receptive field pattern variations are shown in (C). It should be noted that 100% of the mice receiving the TIC surgery develop allodynia. Mice with TIC injury are hypersensitive to cold but not warm temperatures (D). n= 7–10; Two way ANOVA, Fisher post hoc test ****p<0.0001; One way ANOVA, Tukey post hoc ***p<0.001.