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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Mar 24;25(9):1849–1855. doi: 10.1016/j.bmcl.2015.03.051

FIGURE 3.

FIGURE 3

Effect of increasing concentrations of GR134056X and GR135470X on CCK responses at the CCK1R. Shown are CCK-stimulated intracellular calcium dose-response curves on CHO-CCK1R cells in the absence or presence of increasing concentrations of GR134056X (A, B), or GR135470X (C, D), with values expressed as percentages of the response to maximal stimulation achieved by 0.1mM ATP. Background responses were determined by addition of buffer only in the absence of any ligands, while maximal activation by 0.1mM ATP was used as a positive control. Curves shown in B and D represent values above the background stimulated by the agonist activity of the modulators. Data represent means ± S.E.M. of duplicate determinations from at least three to five independent experiments.