TABLE 1.
Concentration of compound (nM) |
+ GI181771X, CCK EC50 (pM) |
+ GR134056X, CCK EC50 (pM) |
+ GR135470X, CCK EC50 (pM) |
---|---|---|---|
0 | 7.0 ± 1.0 | 14 ± 1.0 | 14 ± 1.0 |
0.01 | 13 ± 4.0 | ND | ND |
0.1 | 10 ± 3 | ND | ND |
0.316 | 2.4 ± 0.6 | ND | ND |
1 | 190 ± 120 | ND | ND |
10 | ND | 19 ± 5.0 | 20 ± 8.0 |
100 | ND | 14 ± 4.0 | 51 ± 7.0*** |
1000 | ND | 39 ± 4.0*** | 120 ± 35*** |
p < 0.0001, values compared with control; ND - not determined.