. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2015 Mar 24;25(9):1849–1855. doi: 10.1016/j.bmcl.2015.03.051

TABLE 1.

CCK-stimulated responses at CHO-CCK1R cells in the presence of increasing concentrations of GI181771X, GR134056X, and GR135470X.

Concentration of compound (nM)	+ GI181771X, CCK EC₅₀ (pM)	+ GR134056X, CCK EC₅₀ (pM)	+ GR135470X, CCK EC₅₀ (pM)
0	7.0 ± 1.0	14 ± 1.0	14 ± 1.0
0.01	13 ± 4.0	ND	ND
0.1	10 ± 3	ND	ND
0.316	2.4 ± 0.6	ND	ND
1	190 ± 120	ND	ND
10	ND	19 ± 5.0	20 ± 8.0
100	ND	14 ± 4.0	51 ± 7.0^***
1000	ND	39 ± 4.0^***	120 ± 35^***

^***

p < 0.0001, values compared with control; ND - not determined.