Table 3.
Stratified analysis for the association between LAPTM4B polymorphism and cancer risk by tumor type
| Type of tumor | Num | *2 vs *1 | *1/2 vs *1/1 | *2/2 vs *1/1 | *1/2 + *2/2 vs *1/1 | *2/2 vs *1/2 + *1/1 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | P(H) | OR(95%CI) | P(H) | OR(95%CI) | P(H) | OR(95%CI) | P(H) | OR(95%CI) | P(H) | ||
| Digestive system | 8 | 1.444(1.313-1.588)** | 0.011 | 1.557(1.365-1.777)** | 0.034 | 1.873(1.460-2.402)** | 0.082 | 1.594(1.404-1.809)** | 0.009 | 1.499(1.179-1.906)** | 0.204 |
| Gastrointestinal | 2 | 1.334(1.176-1.513)** | 0.003 | 1.332(1.119-1.584)** | 0.084 | 1.603(1.125-2.285)* | 0.024 | 1.359(1.149-1.607)** | 0.020 | 1.400(0.990-1.981) | 0.069 |
| Gland | 6 | 1.603(1.387-1.853)** | 0.687 | 1.929(1.573-2.364)** | 0.615 | 2.186(1.539-3.104)** | 0.524 | 1.976(1.625-2.403)** | 0.677 | 1.597(1.144-2.228)* | 0.462 |
| Gynecological tumor | 3 | 1.810(1.583-2.069)** | 0.253 | 1.891(1.563-2.287)** | 0.584 | 2.900(2.156-3.901)** | 0.638 | 2.073(1.733-2.480)** | 0.400 | 2.144(1.619-2.839)** | 0.716 |
| Breast cancer | 2 | 1.413(1.222-1.635)** | 0.058 | 1.488(1.227-1.806)** | 0.187 | 1.959(1.338-2.868)** | 0.075 | 1.549(1.286-1.865)** | 0.101 | 1.640(1.132-2.376)* | 0.116 |
| Lung cancer | 3 | 1.454(1.236-1.710)** | 0.026 | 1.467(1.169-1.842)** | 0.458 | 2.073(1.431-3.002)** | 0.004 | 1.563(1.260-1.939)** | 0.164 | 1.748(1.226-2.492)* | 0.006 |
| Others | 2 | 1.309(1.060-1.615)* | 0.007 | 1.063(0.797-1.416) | 0.017 | 2.337(1.420-3.847)** | 0.075 | 2.860(2.184-3.745)** | <0.001 | 2.278(1.403-3.698)** | 0.220 |
*P < 0.05, **P ≤ 0.001, Num: the number of studies, P (H): the P value for test of heterogeneity among studies, Digestive system; include references (Liu et al. 2007; Cheng et al. 2008; Sun et al. 2008; Wang and Zhang 2010; Qi 2010; Yang et al. 2012; Wang et al. 2012; Zhai et al. 2012), Gastrointestinal: include references (Liu et al. 2007; Cheng et al. 2008), Gland: include references (Sun et al. 2008; Wang and Zhang 2010; Qi 2010; Yang et al. 2012; Wang et al. 2012; Zhai et al. 2012), Gynecological tumor: include references (Meng et al. 2011; Xu et al. 2012; Meng et al. 2013), Breast cancer: include references (Fan et al. 2012; Li et al. 2012), Lung cancer: include references (Deng et al. 2005; Li et al. 2006; Tang et al. 2014), others: includes Lymphoma (Sun et al. 2007) and Nasopharyngeal carcinoma (Wang et al. 2013).