Table 3.

The influence of basic clinical and pathological features on the timing of radical cystectomy

Variable	Definition	Number of cases	ARI >84 days	RR >84 days	Time (mean value)	P value
Patient age	>64 yrs vs. <65 yrs	501 vs. 439	5.2%	1.23	79.1 vs. 67.9 days	0.06
Patient sex	Female vs. male	212 vs. 729	5.1%	1.21	75.0 vs. 73.5 days	0.83
Initial cancer stage (TURBT)	NMIBC vs. MIBC	156 vs. 762	9.7%	1.41	105.2 vs. 67.6 days	0.00
Concomitant Cis	Present vs. absent	7 vs. 911	33.5%	2.43	90.4 vs. 73.9 days	0.64
Grade of cancer cells	HG tumors vs. LG tumors	582 vs. 343	11.9%	1.67	75.7 vs. 71.7 days	0.53
Final MIBC stage (RC)	T3&T4 tumors vs. T2 tumors	551 vs. 244	8.6%	1.51	73.2 vs. 63.6 days	0.15
Case load	>15 op/yr vs. <15 op/yr	690 vs. 251	9.4%	1.51	75.2 vs. 70.0 days	0.45
	>30 op/yr vs. <30 op/yr	226 vs. 715	27.6%	2.49	97.6 vs. 66.3 days	0.00

ARI > 84 days – absolute risk increase of RC performed >84 days from diagnosis; Cis – carcinoma in situ, HG – high–grade; LG – low–grade; MIBC – muscle–invasive bladder cancer; NMIBC – non muscle–invasive bladder cancer, op/yr – mean number of RC performed in a centre per year; RC – radical cystectomy, RR > 84 days – relative risk of RC performed >84 days from diagnosis; TURBT – transurethral resection of bladder tumor; yrs – years.