Table 1.

Comparison in the Total Number of Sites that Have Experienced Convergent Substitutions from 2,270 Proteins.

Comparison	Observed Number of Convergent Sites	Observed Number of Divergent Sites	P-Valuea
(I and II) vs. (I and III)b	176 vs. 223	380 vs. 352	0.012
(IV and II) vs. (IV and III)	204 vs. 287	479 vs. 445	0.00022
(V and II) vs. (V and III)	152 vs. 183	325 vs. 270	0.0067
(IV and V and II) vs. (IV and V and III)	14 vs. 4	27 vs. 22	0.083
(IV and V) vs. (IV and VI)	93 vs. 207	75 vs. 273	0.0062*
(IV and V) vs. (IV and VI)c	66 vs. 204	67 vs. 269	0.18

^aG-test of the hypothesis that the number of convergent sites in a branch set is proportional to the number of divergent sites in the same branch set. An asterisk is given if the case branch set has significantly more convergent sites than expected.

^bTwo sets of branches for which the numbers of amino acid sites that have experienced convergent substitutions are compared. Roman numbers refer to the branch labels in figure 1A.

^cAfter the removal of six hearing genes previously reported to be subject to convergent evolution in echolocators.