Fig. 4.

The constructed Bayesian network of human prefrontal cortex in a force-directed layout. Both blue nodes and magenta nodes represent schizophrenia genes (nominal P < 1e-4) except that magenta nodes are pHAR-associated schizophrenia genes. The rest of the nodes (in green) represent other genes in the network. Although some of the blue nodes are located at the periphery of the largest connected component as well as in the small components, all the magenta nodes are in the largest connected component and virtually none of them are peripheral, suggesting that pHAR-associated schizophrenia genes are located in more central positions than other schizophrenia genes in the prefrontal cortex network.