Table 2.
Distribution of anthropometry, hepatic lipid content, fibrosis risk and acoustic structure quantification parameters in different grades of fatty liver n (%)
| Parameter | Controls |
Type 2 diabetes mellitus |
|||
| CAP < 250 dB/m | CAP 250-< 300 dB/m | CAP 300-< 350 dB/m | CAP ≥ 350 dB/m | ||
| Sex (F/M) | 10/10 | 2/4 | 6/4 | 8/11 | 7/5 |
| Body mass index (kg/m²)b | 22.0 ± 2.7 | 26.7 ± 4.6 | 28.3 ± 5.1 | 29.2 ± 4.3 | 32.1 ± 3 |
| Waist-to-hip ratiob | 0.85 ± 0.08 | 1.00 ± 0.03 | 0.91 ± 0.13 | 0.98 ± 0.06 | 1.01 ± 0.05 |
| Liver stiffness (kpa)a | 4.9 (2.9-6.8) | 3.5 (3-6.1) | 5.1 (3.5-11.7) | 5.7 (3.4-12.3) | 6.9 (4.1-70.6) |
| ≥ 7.9 kpac | 0 (0) | 0 (0) | 1 (10) | 5 (26) | 4 (33) |
| NAFLD fibrosis score | - | -0.68 (-2.45-1.25) | 0.29 (-0.3-1.26) | -0.4 (-3.04-1.1) | 0.11 (-1.68-2.28) |
| ≥ 0.676 | 1 (17) | 3 (30) | 2 (11) | 4 (33) | |
| 1H-MR spectroscopy | - | 4.19 (2.69-16.62) | 9.77 (1.56-15.71) | 18.99 (5.66-35.55) | 18.38 (9.42-41.11) |
| (relative lipid signal, %) | |||||
| Asq | |||||
| Mode 1 (red histogram)b | 114 (105-121) | 107 (102-109) | 106 (102-114) | 105 (100-112) | 102 (99-108) |
| Average 1 (red histogram)a | 117 (109-125) | 110 (104-116) | 108 (106-114) | 106 (103-112) | 105 (102-112) |
| Mode 2 (blue histogram)b | 126 (110-135) | 117 (114-126) | 119 (105-125) | 114 (107-119) | 114 (105-121) |
| Average 2 (blue histogram)b | 132 (116-149) | 122 (116-139) | 123 (114-130) | 118 (109-134) | 115 (106-123) |
| Focal disturbance (FD) ratiob | 0.34 (0.12-0.71) | 0.16 (0.03-0.36) | 0.07 (0.03-0.18) | 0.06 (0.02-0.09) | 0.04 (0.02-0.13) |
a
P < 0.05 (Kruskal-Wallis test),
b
P < 0.01 (Kruskal-Wallis test) vs healthy controls;
c
P < 0.05 (exact test for count data), vs healthy controls. ASQ: Acoustic structure quantification; CAP: Controlled attenuation parameter.