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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Circ Cardiovasc Qual Outcomes. 2015 Feb 10;8(2):179–186. doi: 10.1161/CIRCOUTCOMES.114.001306

Table 5.

Factors Associated with Death in Multivariable Analysis

Multivariable Model Without Interaction Term Multivariable Model With Interaction Term
Factor Hazard Ratio (95% Posterior Credible Interval) Hazard Ratio (95% Posterior Credible Interval)
Age 1.03 (1.02-1.04) 1.02 (1.01-1.03)
Male sex 1.23 (1.02-1.50) 1.21 (0.98-1.46)
Race
    White 0.71 (0.55-0.97) 0.69 (0.54-1.01)
    Black 0.98 (0.73-1.37) 0.95 (0.70-1.40)
Left ventricular ejection fraction 0.62 (0.48-0.80) 0.62 (0.48-0.78)
New York Heart Association Class
    II v. I 1.05 (0.82-1.34) 1.07 (0.86-1.39)
    III v. I 2.04 (1.67-2.62) 2.05 (1.67-2.71)
Ischemic disease 1.52 (1.25-1.92) 1.58 (1.28-1.97)
Diabetes mellitus 1.44 (1.23-1.67) 1.45 (1.22-1.68)
Medication
    β-blocker 0.69 (0.60-0.81) 0.69 (0.59-0.79)
    Angiotensin converting enzyme inhibitor 0.92 (0.74-1.12) 0.93 (0.77-1.16)
QRS duration 1.20 (1.03-1.39) 1.21 (1.03-1.41)
ICD therapy
    DEFINITE 0.61 (0.39-0.96) 0.48 (0.30-0.79)
    MADIT-I 0.48 (0.28-0.81) 0.37 (0.22-0.61)
    MADIT-II 0.59 (0.45-0.78) 0.44 (0.31-0.59)
    MUSTT 0.37 (0.20-0.64) 0.27 (0.14-0.49)
    SCD-HeFT 0.73 (0.60-0.89) 0.58 (0.45-0.74)
    Overall 0.54 (0.30-0.95) 0.41 (0.21-0.71)
Heterogeneity in Treatment Effect (Standard Deviation) 0.57 (0.38, 1.04) 0.59 (0.38, 0.99)

Age and ICD therapy interaction - 1.02 (1.01-1.03)