Table 5.
Multivariable Model Without Interaction Term | Multivariable Model With Interaction Term | |
---|---|---|
Factor | Hazard Ratio (95% Posterior Credible Interval) | Hazard Ratio (95% Posterior Credible Interval) |
Age | 1.03 (1.02-1.04) | 1.02 (1.01-1.03) |
Male sex | 1.23 (1.02-1.50) | 1.21 (0.98-1.46) |
Race | ||
White | 0.71 (0.55-0.97) | 0.69 (0.54-1.01) |
Black | 0.98 (0.73-1.37) | 0.95 (0.70-1.40) |
Left ventricular ejection fraction | 0.62 (0.48-0.80) | 0.62 (0.48-0.78) |
New York Heart Association Class | ||
II v. I | 1.05 (0.82-1.34) | 1.07 (0.86-1.39) |
III v. I | 2.04 (1.67-2.62) | 2.05 (1.67-2.71) |
Ischemic disease | 1.52 (1.25-1.92) | 1.58 (1.28-1.97) |
Diabetes mellitus | 1.44 (1.23-1.67) | 1.45 (1.22-1.68) |
Medication | ||
β-blocker | 0.69 (0.60-0.81) | 0.69 (0.59-0.79) |
Angiotensin converting enzyme inhibitor | 0.92 (0.74-1.12) | 0.93 (0.77-1.16) |
QRS duration | 1.20 (1.03-1.39) | 1.21 (1.03-1.41) |
ICD therapy | ||
DEFINITE | 0.61 (0.39-0.96) | 0.48 (0.30-0.79) |
MADIT-I | 0.48 (0.28-0.81) | 0.37 (0.22-0.61) |
MADIT-II | 0.59 (0.45-0.78) | 0.44 (0.31-0.59) |
MUSTT | 0.37 (0.20-0.64) | 0.27 (0.14-0.49) |
SCD-HeFT | 0.73 (0.60-0.89) | 0.58 (0.45-0.74) |
Overall | 0.54 (0.30-0.95) | 0.41 (0.21-0.71) |
Heterogeneity in Treatment Effect (Standard Deviation) | 0.57 (0.38, 1.04) | 0.59 (0.38, 0.99) |
Age and ICD therapy interaction | - | 1.02 (1.01-1.03) |