Table 6.
Transcriptional regulation of genes involved in methanol metabolism and peroxisome formation
| Short name Pp | Description | G-D logFC | G-D adjPV | M-D logFC | M-D adjPV | X-D logFC | X-D adjPV |
|---|---|---|---|---|---|---|---|
| AOX1 | Alcohol oxidase (Pichia pastoris) | 0.28 | 7.00 | *** | 6.64 | *** | |
| AOX2 | Alcohol oxidase (Pichia pastoris) | 0.39 | 7.44 | *** | 7.48 | *** | |
| CTA1 | Catalase A, breaks downhydrogen peroxide in the peroxisomal matrix | 1.48 | * | 5.45 | *** | 6.11 | *** |
| DAK2 | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA) | −0.18 | 4.13 | *** | 2.97 | *** | |
| DAS1 | Dihydroxyacetone synthase variant 1 | 0.21 | 8.91 | *** | 4.72 | *** | |
| DAS2 | Dihydroxyacetone synthase variant 2 | 0.10 | 8.78 | *** | 4.89 | *** | |
| FDH1 | NAD(+)-dependent formate dehydrogenase, protect cells from formate | 0.44 | 8.74 | *** | 8.75 | *** | |
| FGH1 | S-formylglutathione hydrolase; involved in the detoxification of formaldehyde | 0.65 | 5.25 | *** | 4.86 | *** | |
| FLD | glutathione-dependent formaldehyde dehydrogenase | 0.34 | 4.56 | *** | 3.89 | *** | |
| PEX1 | AAA-peroxin | 0.50 | *** | 2.56 | *** | 2.75 | *** |
| PEX10 | Peroxisomal membrane E3 ubiquitin ligase | 0.33 | 3.64 | *** | 4.19 | *** | |
| PEX11 | Peroxisomal membrane protein | 1.01 | *** | 5.40 | *** | 5.57 | *** |
| PEX12 | C3HC4-type RING-finger peroxin and E3 ubiquitin ligase | 0.36 | ** | 2.50 | *** | 3.75 | *** |
| PEX13 | Integral peroxisomal membrane protein | 0.55 | * | 4.39 | *** | 3.90 | *** |
| PEX14 | Peroxisomal membrane peroxin | 0.23 | 3.14 | *** | 3.90 | *** | |
| PEX17 | Peroxisomal membrane peroxin | −0.26 | 2.26 | *** | 2.96 | *** | |
| PEX19 | Chaperone and import receptor for newly-synthesized class I PMPs | −0.07 | 0.75 | *** | 2.10 | *** | |
| PEX2 | RING-finger peroxin and E3 ubiquitin ligase | 0.75 | *** | 3.48 | *** | 3.63 | *** |
| PEX20 | Peroxin 20 | 0.74 | *** | 1.03 | *** | 3.97 | *** |
| PEX22 | Putative peroxisomal membrane protein | 0.11 | 0.55 | * | 0.85 | *** | |
| PEX25 | Peripheral peroxisomal membrane peroxin | −0.19 | 1.09 | *** | 3.29 | *** | |
| PEX28 | Peroxisomal integral membrane peroxin | 0.04 | 0.23 | 1.55 | *** | ||
| PEX29 | Peroxisomal integral membrane peroxin | −0.24 | −0.16 | 0.48 | *** | ||
| PEX3 | Peroxisomal membrane protein (PMP) | 0.37 | ** | 2.27 | *** | 1.30 | *** |
| PEX30 | Peroxisomal integral membrane protein | 0.10 | 0.09 | 0.47 | *** | ||
| PEX31 | Peroxisomal integral membrane protein | 0.36 | 0.93 | * | 2.29 | *** | |
| PEX4 | Peroxisomal ubiquitin conjugating enzyme | 0.76 | *** | 2.03 | *** | 4.45 | *** |
| PEX5 | Peroxisomal membrane signal receptor | 0.29 | 4.63 | *** | 4.87 | *** | |
| PEX6 | AAA-peroxin | 0.82 | *** | 3.53 | *** | 2.62 | *** |
| PEX7 | Peroxisomal signal receptor | −0.22 | 0.30 | 1.98 | *** | ||
| PEX8 | Intraperoxisomal organizer of the peroxisomal import machinery | 0.42 | ** | 2.93 | *** | 3.52 | *** |
| PEX26 | Peroxisomal membrane protein | 0.94 | *** | 3.16 | *** | 4.63 | *** |
| PEX11C | Ortholog of PEX11 | 0.36 | 3.45 | *** | 1.53 | *** |
Log2 fold changes and adjusted P-values (* adjPV < 0.1; ** adjPV < 0.05; *** adjPV < 0.01) are shown (see Additional file 1: Table S1 for detailed data). Up-regulated genes are in bold letters, down-regulated genes in bold and italics.