Table 3.

Main strategies to improve anemia tolerance.

Research study	Main strategies to improve anemia tolerance
Senay et al.[14]	Patient tolerates anemia in the perioperative period
Graffeo et al.[61]	Patient tolerates anemia in the postoperative period
Salpeter et al.[59]	Restrictive conduct towards blood transfusion
Demetriades et al.[63]	To evaluate indexes of tissue perfusion/hypoxia
Murphy & Angelini[60]	Hematocrit is not the ideal indicator of tissue oxygen delivery
Wettstein et al.[65]	Careful and adequate fluid replacement to optimize the microvascular flow and oxygenation in severe anemia
Rasmussen et al.[66]	The infusion of crystalloid (Ringer's lactate) results in less blood loss than colloid
Perel et al.[67]	Correcting hipovolemia with crystalloids, instead of starch solutions, results in lower mortality risk
Araújo Azi et al. [62]	Mechanical ventilation (hyperoxic) assures tissue oxigenation in the presence of severe acute anemia
Marik[72]	Mantain normothermia in critically ill patients (warm hipothermic patients and cool down febrile patients)