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. 2015 Apr 24;9:158. doi: 10.3389/fncel.2015.00158

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Copyright © 2015 Zhao, Ma, Leong, Han, VanDongen, Chen and Goh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MeCP2-regulated dendritic morphology of newborn DG cells in the adult brain. (A) Schematic diagram showing retroviral construct expressing shctrl or shMeCP2. (B) Representative images and tracings from confocal three-dimensional (3D) reconstruction of dendrites of shctrl and shMeCP2-expressing newborn neurons in the DG of adult brain (Scale bar = 20 μm). (C) Quantification of total dendritic length of shctrl or shMeCP2-expressing neurons. Each symbol represents a single neuron. (D) Quantification of total branch number of shctrl or shMeCP2-expressing neurons. (***p < 0.001, Student’s t-test, n = 35 neurons for shctrl and 26 neurons for shMeCP2 groups, from 5 mice per experimental group).