Table 2.
N | Median PFS (months) |
3-Year PFS | HR (95% CI) | P | |
---|---|---|---|---|---|
No RIT | 71 | 19.0 | 44% | 1.0 | |
RIT | 18 | 53.0 | 56% | 0.7 (0.4–1.5) | 0.36 |
Disease Bulk ≤5 cm | 67 | 30.8 | 49% | 1.0 | |
Disease Bulk >5 cm | 22 | 14.8 | 36% | 1.5 (0.9–2.7) | 0.15 |
Other Histologies | 27 | 18.1 | 37% | 1.0 | |
CLL/SLL | 62 | 23.8 | 50% | 0.8 (0.5–1.5) | 0.56 |
Related Donor | 47 | 37.6 | 53% | 1.0 | |
Unrelated Donor | 42 | 19.0 | 38% | 1.1 (0.7–1.8) | 0.76 |
Non-High-Risk Cytogeneticsa | 33 | 53.0 | 61% | 1.0 | |
High-Risk Cytogeneticsa | 14 | 19.9 | 43% | 1.2 (0.5–2.8) | 0.63 |
PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; RIT, radioimmunotherapy; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; MRD, matched related donor;.
“High-risk cytogenetics” were those patients with CLL/SLL that harbored deletion 11q and/or deletion 17p; all others with CLL/SLL from whom cytogenetic data were available were considered “non-high-risk”.