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. Author manuscript; available in PMC: 2015 Apr 24.
Published in final edited form as: Endocrinology. 2007 Jan 4;148(4):1823–1834. doi: 10.1210/en.2006-1241

Figure 4.

Figure 4

The plasma corticosterone response to restraint was attenuated by sucrose and saccharin drink in Control rats, and CVS facilitated the plasma corticosterone response to restraint regardless of type of drink. The time course of restraint-stress induced plasma corticosterone for Control (A) and CVS (B) rats receiving sucrose, saccharin or water twice daily via sippers (in addition to ad lib access to food and water). (C) The integrated (area under the curve, AUC) plasma corticosterone response to restraint. *p<0.05 vs water, #p<0.05 vs Control. Not noted on figure: all values at 20, 40, and 60 min are greater than 0 min. n=7–9/group. Please note that the statistics depicted on the figure resulted from a three-way ANOVA comparing DRINK, CVS, and TIME. A separate planned 2-way ANOVA at the 0-min time point revealed a main effect of CVS to increase basal plasma corticosterone, which is not indicated on the figure.