Table 1.
The most highly up- (A) or down- (B) regulated named sequences were identified from the list of 361 regulated transcripts. Transcripts are listed from most to least regulated. Log2 (Fold change (FC)) represents the log2 of the difference in log2 probe intensity between FSL animals relative to SD animals. Positive log2 (FC) values indicate increased gene expression within FSL animals relative to SD animals, while negative log2 (FC) values indicate decreased gene expression within FSL animals relative to SD animals. Probe set ID represents the proprietary Affymetrix identification method associated with the specific microarray chip.
| Probe set ID | Gene name | Gene symbol | Log2 (FC) |
|---|---|---|---|
| A. Up-regulated sequences | |||
| 1368826_at | Catechol-O-methyltransferase | COMT | 6.14 |
| 1371970_at | Family with sequence similarity 111, member A | Fam111a | 5.51 |
| 1383211_at | Tuftelin 1 | Tuft1 | 5.26 |
| 1395020_at | Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | Plekhh1 | 5.25 |
| 1387839_at | RT1 class Ib gene, H2-TL-like, grc region (N1)///RT1 class Ib gene, H2-TL-like, grc region(N2)///RT1 class Ib gene, H2-TL-like, grc region (N3) | RT1-N1///RT1-N2///RT1-N3 | 4.62 |
| 1369144_a_at | Potassium voltage gated channel, Shal-related family, member 3 | Kcnd3 | 3.61 |
| 1390777_at | Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, Saccharomyces cerevisiae)-like | Sc5dl | 2.69 |
| 1393842_at | Coiled-coil domain containing 77 | Ccdc77 | 2.54 |
| 1380577_at | ATP-binding cassette, sub-family G (WHITE), member 2 | Abcg2 | 2.53 |
| 1378346_at | Lipin 2 | Lpin2 | 2.27 |
| B. Down-regulated sequences | |||
| 1391262_at | Similar to SUMO/sentrin specific protease 5///SUMO/sentrin specific protease 5 | RGD1564247///Senp5 | −6.21 |
| 1393623_at | Tripartite motif-containing 25 | TRIM25 | −5.72 |
| 1397439_at | Similar to diacylglycerol kinase epsilon | LOC497978 | −4.81 |
| 1377133_at | Hypothetical protein LOC680687 | LOC680687 | −4.81 |
| 1372120_at | Ubiquitin-like modifier activating enzyme 5 | Uba5 | −3.98 |
| 1377442_at | HtrA serine peptidase 4 | HTRA4 | −3.81 |
| 1368943_at | Ribonuclease, RNase A family 4 | Rnase4 | −3.72 |
| 1395126_at | Fc receptor-like S, scavenger receptor | Fcrls | −3.66 |
| 1388071_x_at | RT1 class Ib, locus Aw2 | RT1-Aw2 | −3.43 |
| 1388060_at | Synaptotagmin XII | Syt12 | −2.74 |