Table 1.
Effect of dietary supplementation with C, Q and both compounds on metabolic parameters in a rat model of MetS. Body weight and metabolic parameters in rats fed control diets without (Crtl) or with (HFr) 10% (w/v) fructose in the water, or HFr diets supplemented with catechin (C), quercetin (Q) or both (CQ) (20 mg/Kg/d). Glucose, insulin, tryglicerides, TBARS and adiponectin levels were measured in plasma.
| Parameter | Groups | ||||
|---|---|---|---|---|---|
| Ctrl | HFr | HFr+C | HFr−Q | HFr+CQ | |
| Food intake (g/d) | 16.3 ± 0.5 | 15.7 ± 0.5 | 14.3 ± 0.4 | 15.4 ± 0.6 | 14.5 ± 0.6 |
| Water intake (ml/d) | 43.3 ± 0.9a | 52.5 ± 0.8b | 53.0 ± 0.9b | 54.0 ± 1.0b | 52.6 ± 0.9b |
| Energy intake (Kcal/d) | 45.4 ± 1.4a | 64.6 ± 1.7b | 61.0 ± 1.5b | 64.3 ± 1.8b | 61.3 ± 2.1b |
| Body weight (BW) (g) | 295 ± 8 | 290 ± 8 | 261 ± 8 | 288 ± 12 | 279 ± 12 |
| Epididymal adipose tissue (mg)/BW (g) | 4.3 ± 0.3a | 6.4 ± 1.4b | 4.4 ± 0.5a | 4.3 ± 0.6a | 4.0 ± 0.9a |
| Glucose (mM) | 4.5 ± 0.2 | 4.8 ± 0.4 | 4.0 ± 0.1 | 4.4 ± 0.1 | 4.7 ± 0.2 |
| Insulin (µU/mL) | 10.9 ± 1.0a | 24.8 ± 2.4b | 15.7 ± 0.9a | 16.6 ± 1.0a | 15.2 ± 0.9a |
| HOMA IR (mmol/L × µU/ml) | 2.2 ± 0.2a | 5.3 ± 0.5b | 2.8 ± 0.3a | 3.2 ± 0.3a | 3.2 ± 0.3a |
| Triglycerides (mM) | 0.65 ± 0.02a | 1.21 ± 0.08b | 0.81 ± 0.06a,c | 0.89 ± 0.02c | 0.64 ± 0.03a |
| TBARS (µM) | 0.9 ± 0.0a | 1.3 ± 0.1b | 1.0 ± 0.0a,b | 0.8 ± 0.1a | 0.71 ± 0.1a |
| Adiponectin (ng/ml) | 24.5 ± 2.1a | 9.7 ± 2.0b | 20.5 ± 4.3a | 19.6 ± 2.8a | 29.5 ± 1.0a |
Values are mean ± SEM, n = 6. Values with different superscripts are significantly different, P < 0.05. HOMA-IR, homeostatic model assessment-insulin resistance.