Figure 2.

Relative risks of dementia, brain infarcts, and brain microbleeds by midlife by body mass index (weight in kilograms divided by height in meters squared; BMI), the Age, Gene/Environment Susceptibility-Reykjavik Study, 1967–2006 (n = 3,864). Relative risks (on an arithmetic scale) for overweight (BMI of 25–29.9) and obese (BMI ≥30) participants were compared with those of normal-weight (BMI 18.5–24.9) participants using Poisson models that were adjusted for sex, age in midlife, number of follow-up years, presence of the Apolipoprotein ε4 allele, educational level, intracranial volume, physical activity level, systolic and diastolic blood pressures, and serum cholesterol level in midlife and for coronary artery calcium, prevalent coronary heart disease, hypertension, diabetes, depression, and drinking and smoking habits in late life. The models for dementia were further adjusted for brain infarcts and percentage of white matter lesion volume. Bars, 95% confidence intervals.