Table 2.
Predictors of Mortality in 395 HIV- and TB-infected Participants Under Observed Implementation Fidelity to CD4-Stratified Timing of Antiretroviral Therapy Initiation, Integrating Tuberculosis and Antiretroviral Treatment Study, 2007–2009
| Predictor | Crude |
Adjusted |
||||
|---|---|---|---|---|---|---|
| Full Model |
Reduced Model |
|||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Sex | ||||||
| Male | 1.78 | 0.86, 3.65 | 1.97 | 0.76, 5.09 | 2.37 | 1.00, 5.61 |
| Female | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
| Age, years | ||||||
| <30 | 1.36 | 0.44, 4.17 | 1.26 | 0.32, 4.96 | ||
| 30–39 | 1.00 | Referent | 1.00 | Referent | ||
| 40–49 | 1.72 | 0.71, 4.14 | 1.86 | 0.64, 5.37 | ||
| ≥50 | 2.40 | 0.82, 7.07 | 2.96 | 0.77, 11.40 | ||
| Type of tuberculosis | ||||||
| Smear positive, pulmonary | 1.00 | Referent | 1.00 | Referent | ||
| Smear negative, pulmonary | 2.01 | 0.81, 4.98 | 1.43 | 0.48, 4.24 | ||
| Extrapulmonary | 2.05 | 0.71, 5.91 | 1.11 | 0.07, 17.79 | ||
| CD4 count, cells/mm3 | ||||||
| <50 | 5.99 | 2.19, 16.36 | 7.66 | 2.27, 25.80 | 7.30 | 2.29, 23.30 |
| 50–99 | 1.81 | 0.53, 6.19 | 1.92 | 0.47, 7.86 | 1.94 | 0.49, 7.59 |
| 100–199 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
| 200–350 | 1.36 | 0.44, 4.17 | 2.19 | 0.58, 8.20 | 1.95 | 0.56, 6.79 |
| Body mass indexa | ||||||
| Underweight (<18.5) | 1.92 | 0.87, 4.27 | 2.46 | 0.94, 6.20 | 2.21 | 0.89, 5.62 |
| Not underweight (≥18.5) | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
| TB treatment intolerance | ||||||
| Yes | 12.33 | 5.56, 27.31 | 12.75 | 4.69, 34.71 | 12.65 | 4.82, 33.20 |
| No | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
| Contraindication to any ARV | ||||||
| Yes | 0.90 | 0.20, 4.04 | 1.43 | 0.48, 4.24 | ||
| No | 1.00 | Referent | 1.00 | Referent | ||
| WHO stage | ||||||
| 4 | 1.34 | 0.59, 3.01 | 1.28 | 0.10, 16.10 | ||
| 3 | 1.00 | Referent | 1.00 | Referent | ||
| ART initiation | ||||||
| Not per strategy | 4.25 | 1.79, 10.07 | 2.52 | 0.93, 6.86 | 2.47 | 0.93, 6.55 |
| Per strategy | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Abbreviations: ART, antiretroviral therapy; ARV, antiretroviral; CI, confidence interval; HIV, human immunodeficiency virus; OR, odds ratio; TB, tuberculosis; WHO, World Health Organization.
a Weight (kg)/height (m)2.