Table 5.
The AUC0–24h of OX in tissues after IV administration of free OX and liposomes to mice (n=6)
| Formulation | Heart | Liver | Spleen | Lung | Kidney |
|---|---|---|---|---|---|
| free OX | 1,646 | 1,648 | 2,333 | 1,901 | 2,104 |
| OX-liposomes | 2,039 | 2,910 | 2,198 | 2,572 | 3,082 |
| GA-OX-liposomes | 2,257 | 11,162 | 2,547 | 2,781 | 2,952 |
| Ratioa | 1.37 | 6.77* | 1.09 | 1.46 | 1.40 |
| Ratiob | 1.11 | 3.84* | 1.16 | 1.08 | 0.96 |
| Ratioc | 1.24 | 1.77 | 0.94 | 1.35 | 1.46 |
Notes:
a
The ratio was AUC (GA-OX-liposomes)/AUC (free OX).
b
The ratio was AUC (GA-OX-liposomes)/AUC (OX-liposomes).
c
The ratio was AUC (OX-liposomes)/AUC (free OX).
*
P<0.05.
Abbreviations: AUC, area under the drug concentration-time curve values; GA, glycyrrhetinic acid; IV, intravenous; OX, oxaliplatin.