Table 1.

Overcoming crizotinib resistance patterns with selective therapies in ALK-rearranged NSCLC

Resistance mechanism	Targeted treatment
1151Tins	Not identified
C1156Y	Alectinib, X396
F1174C	Alectinib, ASP3026; resistant to ceritinib
F1174L	Not identified
G1269A	Ceritinib
G1202R	Resistant to ceritinib
I1171T	Ceritinib; resistant to alectinib
L1196M	Alectinib, AP26113, ceritinib, ASP3026, X396
L1152R	Not identified
S1206Y	Ceritinib
Bypassing EGFR pathway	AP26113 – dual ALK/EGFR inhibitor

Abbreviations: NSCLC, non-small-cell lung cancer; ALK, anaplastic large-cell kinase; EGFR, epidermal growth factor receptor.