Figure 8. Scheme illustration of how NAC and AAP protect mitochondria against oxidative damage in hADMSC, and subsequently rescue the cell from necroptosis and apoptosis.

Both NAC and AAP protect cells from oxidative stress-induced cell death via inhibiting mitoptosis and necroptosis in hADMSCs. NAC/AAP suppress necroptosis via decreasing the translocation of AIF, and thus stopping the formation of necrosome. Stabilization of mitochondrial integrity prevents the secretion of apoptotic factors that are resided in the mitochondria.