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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Immunol. 2014 Oct 15;193(10):4980–4987. doi: 10.4049/jimmunol.1400313

Figure 1. RvD1 attenuates Poly(I:C)-induced IL-6 and IL-8 production in primary human airway epithelial cells (SAECs).

Figure 1

Two strains of human primary SAECs were pre-treated with RvD1 for 30 minutes prior to the addition of poly(I:C) (5μ/ml) for 24 hours. Supernatants from the cultures were collected and subjected to ELISA to determine the levels of (A and C) IL-6 and (B and D) IL-8. (E and F) hSAECs were treated with poly(I:C) (5μg/ml) for 15 minutes prior to treatment with RvD1 (100nM) for a further 24 hours. Supernatants were collected and the levels of IL-6 and IL-8 were determined as described earlier. Data shown are mean ± SD of triplicate cultures, from one representative experiment of 3 performed. ###p<0.001 as compared to the non-treated control. *p<0.05; **p<0.01, ***p<0.001 compared to poly(I:C) stimulated culture, using one-way ANOVA with Bonferroni post-tests.