Table 3.
Differences in Global Normalized Brain Volume Measures between Patients and Controls
| Multiple Sclerosis | Normal Controls | P-Value | Effect Size | |
|---|---|---|---|---|
| Compartmental Volume | (n = 61) | (n = 30) | (d) | |
| uGMF | .514 ±.028 | .522 ±.021 | .019* | −.323 |
| c1GMF | .521 ±.028 | .529 ±.021 | .014* | −.323 |
| c2GMF | .513 ±.028 | .522 ±.021 | .011* | −.364 |
| cGMF | .520 ±.028 | .529 ±.021 | .008* | −.364 |
| uWMF | .315 ±.019 | .324 ±.020 | .108 | −.461 |
| c1WMF | .308 ±.019 | .316 ±.020 | .131 | −.410 |
| c2WMF | .317 ±.018 | .324 ±.020 | .200 | −.368 |
| cWMF | .310 ±.018 | .316 ±.020 | .238 | −.315 |
| uBPF | .830 ±.031 | .846 ±.017 | .002* | −.640 |
| c1BPF | .830 ±.031 | .846 ±.017 | .002* | −.640 |
| c2BPF | .830 ±.030 | .846 ±.017 | .002* | −.656 |
| cBPF | .830 ±.030 | .846 ±.017 | .002* | −.656 |
Values in table are mean ± standard deviation regarding the uncorrected (u, raw) versus corrected segmentations after correcting misclassifications related to either deep gray matter contour (c1), T1 hypointensities (c2), or both (c, dually corrected).
GMF = gray matter fraction; WMF = white matter fraction; BPF = brain parenchymal fraction.
P-values are group differences based on linear regression modeling controlling for age and gender
*
P <.05.