Table 4.
MRI Differences Based on Cognitive Status in the Multiple Sclerosis Group (n = 61)
| Cognitively Impaired | Cognitively Preserved | P-Value | Effect size | |
|---|---|---|---|---|
| Brain MRI Metric | (n = 23) | (n = 38) | (d) | |
| uGMF | .505 ±.030 | .520 ±.026 | .121 | −.534 |
| c1GMF | .512 ±.029 | .527 ±.026 | .116 | −.545 |
| c2GMF | .504 ±.030 | .519 ±.026 | .101 | −.534 |
| cGMF | .510 ±.030 | .526 ±.026 | .096 | −.570 |
| uWMF | .312 ±.015 | .317 ±.021 | .208 | −.274 |
| c1WMF | .305 ±.015 | .310 ±.020 | .210 | −.283 |
| c2WMF | .314 ±.014 | .318 ±.020 | .268 | −.232 |
| cWMF | .307 ±.015 | .312 ±.020 | .270 | −.283 |
| uBPF | .817 ±.034 | .837 ±.026 | .033* | −.661 |
| c1BPF | .817 ±.034 | .837 ±.026 | .033* | −.661 |
| c2BPF | .818 ±.034 | .837 ±.026 | .034* | −.628 |
| cBPF | .818 ±.034 | .837 ±.026 | .034* | −.628 |
| T1LV (ml) | 1.70 ± 1.10 | 1.09 ±.983 | .030* | .585 |
| T2LV (ml) | 2.53 ±.811 | 2.16 ±.730 | .078 | .480 |
Values in table are mean ± standard deviation; uncorrected (u, raw) versus corrected segmentations after correcting misclassifications related to either deep gray matter contour (c1), T1 hypointensities (c2), or both (c, dually corrected).
GMF = gray matter fraction; WMF = white matter fraction; BPF = brain parenchymal fraction; T1LV = total brain T1 hypointense lesion volume; T2LV = total brain T2 hyperintense lesion volume.
The 2 cognition groups were defined and analyzed as described in the Methods section.
P-values are comparisons between the 2 groups based on linear regression modeling controlling for age, gender, and depressive symptoms
*
P <.05.