Table 5.
Correlations between MRI and Clinical Status in the Multiple Sclerosis Group (n = 61)
| Expanded Disability | ||||||
|---|---|---|---|---|---|---|
| Status Scale Score |
Timed 25 Foot Walk |
Disease Duration |
||||
| Brain MRI Metric | r | P-Value | r | P-Value | r | P-Value |
| uGMF | −.230 | .075 | −.233 | .071 | −.343 | .007* |
| c1GMF | −.224 | .083 | −.220 | .089 | −.352 | .006* |
| c2GMF | −.231 | .073 | −.234 | .070 | −.341 | .007* |
| cGMF | −.223 | .084 | −.222 | .085 | −.354 | .005* |
| uWMF | −.152 | .242 | −.069 | .596 | −.053 | .688 |
| c1WMF | −.170 | .190 | −.083 | .523 | −.056 | .663 |
| c2WMF | −.141 | .278 | −.050 | .702 | −.036 | .784 |
| cWMF | −.163 | .208 | −.071 | .586 | −.029 | .824 |
| uBPF | −.289 | .024* | −.171 | .187 | −.303 | .018* |
| c1BPF | −.289 | .024* | −.171 | .187 | −.303 | .018* |
| c2BPF | −.293 | .022* | −.171 | .188 | −.302 | .018* |
| cBPF | −.293 | .022* | −.171 | .188 | −.302 | .018* |
| T1LV | .181 | .163 | −.095 | .465 | −.062 | .636 |
| T2LV | .100 | .442 | −.1621 | .212 | −.117 | .368 |
Uncorrected (u, raw) versus corrected segmentations after correcting misclassifications related to either deep gray matter contour (c1), T1 hypointensities (c2), or both (c, dually corrected).
GMF = gray matter fraction; WMF = white matter fraction; BPF = brain parenchymal fraction; T1LV = log of the total brain T1 hypointense lesion volume; T2LV = log of the total brain T2 hyperintense lesion volume.
Spearman rank correlation r and P-values are shown
*
P <.05.