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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Rev Neurol (Paris). 2015 Feb 25;171(3):236–251. doi: 10.1016/j.neurol.2015.01.563

Figure 2.

Figure 2

Interictal activity generated in vitro by the subiculum obtained from mTLE-HS patients (from Cohen et al., 2002).

A. Multiple extracellular recordings showing spontaneous synchronous population activity within the subiculum.

B. Pharmacological characterization of interictal activities: suppression by the GABAA receptor antagonists (bicuculline) and glutamate AMPA and NMDA receptors antagonists (NBQX + APV).

C. Behavior of different cell types during interictal activities. The top trace is an intracellular recording, the lower one an extracellular recording. Interneurons (top trace) discharge before and during the first phase of the burst. Pyramidal cells are hyperpolarized in the usually hot (middle trace) but can also be depolarized (bottom traces).