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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Rev Neurol (Paris). 2015 Feb 25;171(3):236–251. doi: 10.1016/j.neurol.2015.01.563

Figure 9.

Figure 9

Synaptic characteristics of interictal (IID) and preictal discharges (PID).

A: Intracellular recording from a subicular pyramidal cell (I) with a local extracellular recording (E). This cell received hyperpolarizing synaptic inputs during IIDs (open circle) both before and after convulsants were added. In contrast, it was depolarized during PIDs (filled circle) in the presence of convulsants.

B: IIDs and PIDs coexisted during the transition to ictal discharges (left trace). Bicuculline (bic) blocked IIDs, but not PIDs (middle left). The NMDA receptor blocker D,L-AP5 (100 μM) did not change PIDs (middle right), but the AMPA receptor antagonist NBQX (10 μM) suppressed them (right).

C: Distinct reversal potentials for synaptic events associated with IIDs and PIDs.