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. Author manuscript; available in PMC: 2016 Mar 2.
Published in final edited form as: Mol Pharm. 2015 Jan 27;12(3):742–750. doi: 10.1021/mp500581r

Figure 2.

Figure 2

Assessment of the relative stability of siRNA/co-oligomer complexes formed with (A) MTC co-oligomer 14, (B) hybrid glycerol–MTC co-oligomer 12, or (C) glycerol co-oligomer 10. Complexes were formulated in PBS, pH 7.4, at a ± ratio of 4.77:1, incubated at room temperature for 30 min, and then placed in a 37 °C heat block for the indicated amount of time (in hours) before loading onto the gel. Reappearance of the siRNA band indicates release of siRNA from the complex; the time corresponding to first reappearance is denoted with an arrow.