Skip to main content
. Author manuscript; available in PMC: 2015 Apr 24.
Published in final edited form as: Dev Neurobiol. 2008 Nov;68(13):1441–1453. doi: 10.1002/dneu.20670

Fig. 1. Expression of NAV2 protein in C. elegans rescues the PLM elongation defect in the mechanosensory neurons of unc-53 mutant worms.

Fig. 1

(A) Top panel: a diagram of the mechanosensory neurons in wild-type C. elegans (adapted from Savage et al., 1989) with the PLM neuron highlighted in green; bottom panels: representative fluorescent images showing the extension of the PLM neuron in wild-type (EG1194), unc-53(e404) mutant, and unc-53(e404) worms expressing the full length human NAV2 protein under the regulation of the mec7 promoter. Expression of NAV2 in unc-53 mutants rescues the mechanosensory neuron defects as indicated by an increase in the relative length of the PLM. The PLM and ALM cell bodies are labeled (white line) and the most anterior axonal projection of the PLM (arrow) is shown in the panels. Scale bar is 50 μm. (B) The distribution of the relative PLM axon length is shown for wild-type (empty bars), unc-53 (filled bars) and unc-53 rescued with the Pmec7∷NAV2∷FLAG extra-chromosomal array (red); data compiled from two transgenic lines.